Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human UBE2O protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.2 - 5.0 ?g/mL.?For immunocytochemistry, a concentration range of 0.5 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2820188 (BioLegend Cat. No. 870201) AB_2820189 (BioLegend Cat. No. 870202)
Antigen Details
- Structure
- Human UBE2O is a 1,292 amino acid protein with a predicted molecular mass of 141 kD and observed molecular mass of ~200 kD
- Distribution
-
Tissue distribution: Brain, skeletal muscle, heart
Cellular distribution: Nucleus, cytosol - Function
- UBE2O is an E2/E3 hybrid ubiquitin-protein ligase that is crucial for protein ubiquitination and degradation.
- Cell Type
- Astrocytes, Microglia, Neurons, Oligodendrocytes
- Biology Area
- Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Ubiquitin/Protein Degradation
- Molecular Family
- Ligases
- Antigen References
-
- Ullah K, et al. 2019. FEBS J. 286(11):2018-2034.
- Chen S, et al. 2018. J Biol Chem. 293(29):11296-11309.
- Mashtalir N, et al. 2014. Mol Cell. 54(3):392-406.
- Gene ID
- 63893 View all products for this Gene ID
- UniProt
- View information about UBE2O on UniProt.org
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