Product Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human VCP Protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.5 - 10 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2861105 (BioLegend Cat. No. 870901) AB_2861106 (BioLegend Cat. No. 870902)
Antigen Details
- Structure
- VCP is an 806 amino acid protein with predicted molecular mass of ~89 kD and observed molecular mass at ~ 97 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytosol, endoplasmic reticulum, nucleus, extracellular, and lysosome - Function
- Protein Trafficking, protein clearance
- Interaction
- Forms homohexamers and a ternary complex with STX5A and NSFLC. Interacts with NPLOC4, UFD1, and clathrin.
- Cell Type
- Astrocytes, Dopaminergic Neurons, Endothelial cells, Epithelial cells, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
- Biology Area
- Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Signal Transduction, Ubiquitin/Protein Degradation
- Molecular Family
- Endoplasmic Reticulum Markers, Neurotransmitter Receptor Trafficking/Endocytosis, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Lan B, et al. 2017. Curr Mol Med. 17(9):608.
- van den Boom J & Meyer H. 2018. Mol Cell. 69(2):182.
- Van Mossevelde S, et al. 2018. Nat Rev Neurol. 14(6):363.
- Gene ID
- 7415 View all products for this Gene ID 269523 View all products for this Gene ID 116643 View all products for this Gene ID
- UniProt
- View information about VCP on UniProt.org
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