Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human optineurin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 2.0?- 10??g/mL. For immunocytochemistry, a concentration range of 2.0?- 10?μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2820186 (BioLegend Cat. No. 870101) AB_2820187 (BioLegend Cat. No. 870102)
Antigen Details
- Structure
- Human optineurin is a 577 amino acid protein with a predicted molecular mass of 66 kD and an observed molecular mass of 74 kD.
- Distribution
-
Tissue distribution: Widely expressed in tissues
Cellular distribution: Nucleus, endosome, cytosol, Golgi apparatus, mitochondrion, lysosome
- Function
- Optineurin plays an important role in the maintenance of the Golgi complex, membrane trafficking and exocytosis.
- Interaction
- Interacts with myosin VI and Rab8
- Cell Type
- Astrocytes, Neurons
- Biology Area
- Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance
- Molecular Family
- Adaptor Proteins
- Antigen References
-
- Osawa T, et al. 2011. Neuropathology. 31:569-74.
- Ying H, Yue BY. 2012. Int. Rev. Cell. Mol. Biol. 294: 223-58.
- Korac J, et al. 2013. J. Cell. Sci. 126: 580-92.
- Gene ID
- 10133 View all products for this Gene ID
- UniProt
- View information about Optineurin on UniProt.org
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