Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD155
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Blocking - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding of 0.2 ?g/mL biotinylated recombinant mouse TIGIT to 1 ?g/mL immobilized recombinant mouse CD155-Fc chimera. ND50 = 0.05 – 0.25 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2890862 (BioLegend Cat. No. 942103) AB_2890862 (BioLegend Cat. No. 942104)
Antigen Details
- Structure
- Disulfide-linked homodimer
- Distribution
-
Highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin, preferentially expressed on Th17 cells.
- Function
- Mediates NK cell adhesion and triggers NK cell effector functions
- Interaction
- NK cell, T cell
- Ligand/Receptor
- Vitronectin, nectin-3, DNAM-1/CD226, CD96, and TIGIT
- Cell Type
- Dendritic cells, Th17, Thymocytes
- Biology Area
- Adaptive Immunity, Cell Adhesion, Cell Motility/Cytoskeleton/Structure, Neuroscience
- Molecular Family
- Adhesion Molecules, Soluble Receptors
- Antigen References
- 1. He Y, et al. 2000. Proc. Natl. Acad. Sci. USA. 97:79-84.2. Bottino C, et al. 2003. J. Exp. Med. 198:557-67.3. Fuchs A, et al. 2004. J. Immun. 172: 3994-3998.4. Reymond N, et al. 2004. J. Exp. Med. 199:1331-41.5. Koike S, et al. 1990. EMBO J. 9: 3217-3224.6. Mendelsohn CL, et al. 1989. Cell 56:855-65.
- Gene ID
- 52118 View all products for this Gene ID
- UniProt
- View information about CD155 on UniProt.org
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