Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD27 (TNFRSF7)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding of 0.08 ?g/mL recombinant mouse CD27L to 2 ?g/mL immobilized recombinant mouse CD27 (TNFRSF7)-Fc. ND50 = 0.3 - 1.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2890861 (BioLegend Cat. No. 942003) AB_2890861 (BioLegend Cat. No. 942004)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Resting T and B cells, NK cells, hematopoietic progenitor cells
- Function
- Induces T-cell co-stimulation and B-cell activation, plasma cell differentiation
- Interaction
- Activated T and B cells, antigen-presenting cells (APC)
- Ligand/Receptor
- CD27L (CD70)
- Cell Type
- B cells, Hematopoietic stem and progenitors, NK cells, Plasma cells, T cells, Thymocytes
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, Immune Checkpoint Receptors, Soluble Receptors
- Antigen References
-
- Camerini D, et al. 1991. J Immunol. 147:3165-9.
- Gravestein LA, et al. 1993. Eur J Immunol. 23:943-50.
- Prasad KV, et al. 1997. Proc Natl Acad Sci. 94:6346-51.
- Kato K, et al. 2007. Exp Hematol. 35:434-42.
- van Montfrans J M, et al. 2012. J Allergy Clin Immunol. 129:787-793.
- Goto N, et al. 2012. Leuk Lymphoma. 53:1494-500.
- Huang J, et al. 2013. J Immunol. 190:6250-8.
- Gene ID
- 21940 View all products for this Gene ID
- UniProt
- View information about CD27 on UniProt.org
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