Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Partial recombinant human CREB1 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified - Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0?- 5.0??g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone recognizes endogenous CREB1 proteins at 43 kD in both human and mouse cell lysates.
- RRID
- AB_2894537 (BioLegend Cat. No. 948301) AB_2894537 (BioLegend Cat. No. 948302)
Antigen Details
- Structure
- CREB1 contains 327 amino acids at a predicted molecular weight at 35 kD.
- Distribution
-
Ubiquitously expressed /Nucleus
- Function
- Under physiological conditions, CREB1 protein maintain cellular survival, proliferation, anti-inflammatory immune responses and modulates the development of the nervous system by serving as a neuroprotective role. Under pathological conditions, increased level of CREB1 associates with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin’s lymphoma, chronic lymphatic leukemia (CLL), melanoma, hepatocellular, renal cell, ovarian, prostate, lung, gastric, esophageal, pancreatic, and breast tumors. CREB1 is also involved in the aging process by regulating the downstream signals of mitochondria dysfunction.
- Interaction
- CREB1 interacts with CREBBP, CRTC2, EP300, CRTC1, JUN, AKT1, CAMK4, FOS, RPS6KA1, RPS6KA3, CaMKII, CaMKIV, PKA, PKC, MSK, RSK, AKT, and MK2.
- Cell Type
- B cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, NK cells, T cells
- Biology Area
- Cell Biology, Transcription Factors
- Antigen References
-
- Andre S, et al. 2020. Cell Mol Life Sci. 77:4049-4067
- Pei-Hsuan L, et al. 2020. Diagnostics. 10:295
- Kensuke S, et al. 2011. J Neurochem. 116:1-9
- Andy YW, et al. 2010. J Immunol. 185:6413-6419
- TA, et al. 2002. EMBO J. 21:53-63
- Gene ID
- 1385 View all products for this Gene ID
- UniProt
- View information about CREB1 on UniProt.org
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