Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD272 (BTLA)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between mouse BTLA-Fc chimera and mouse HVEM-Fc chimera. Ultra-LEAFTM purified anti-mouse CD272 (BTLA) antibody blocks the binding of 0.03 ?g/mL recombinant mouse HVEM-Fc chimera to 1 ?g/mL immobilized recombinant mouse BTLA-Fc chimera. ND50 range: 0.08 – 0.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2904452 (BioLegend Cat. No. 941803) AB_2904452 (BioLegend Cat. No. 941804)
Antigen Details
- Structure
- An Ig superfamily co-inhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4
- Distribution
-
Lymphocytes, T cells, B cells, macrophages, dendritic cells, NKT cells and natural killer cells.
- Function
- Negative regulator of T cell activation and proliferation, attenuate B cell proliferation upon associating with its known ligand, herpes virus entry mediator (HVEM)
- Interaction
- Lymphocytes
- Ligand/Receptor
- HVEM
- Cell Type
- B cells, Dendritic cells, Lymphocytes, Macrophages, NK cells, NKT cells, T cells
- Biology Area
- Adaptive Immunity, Immunology, Innate Immunity
- Molecular Family
- Immune Checkpoint Receptors
- Antigen References
-
- Watanabe N, et al. 2003. Nat. Immunol. 4: 670-9
- Gavrieli M, et al. 2003. Biochem. Biophys. Res. Commun. 312: 1236-43
- Gonzalez LC, et al. 2005. Proc. Natl. Acad. Sci. 102: 1116-21
- Sedy JR, et al. 2005. Nat. Immunol. 6: 90-8
- Murphy KM, et al. 2006. Nat. Rev. Immunol. 6: 671-81
- Gene ID
- 208154 View all products for this Gene ID
- UniProt
- View information about CD272 on UniProt.org
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