Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to human BLNK phosphorylated at Tyrosine 96
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, ICFC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 ?g/mL.?For immunocytochemistry, a concentration range of 1.25 - 5.0 μg/mL is recommended.?For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This product has high background in WB if used at concentrations above 0.2 μg/mL.
This product is not suitable for ICC if cells are fixed with methanol only.
Antigen Details
- Structure
- BLNK is a 456 amino-acid protein with a predicted molecular weight of 50 kD.
- Distribution
-
BLNK is expressed in cytoplasm of B cells.
- Function
- Activation of BLNK plays a critical role in B cell proliferation, differentiation, and apoptosis.
- Interaction
- BLNK interacts with Grb2, Vav, PLCγ2, and Nck1.
- Cell Type
- B cells
- Biology Area
- Cell Biology
- Molecular Family
- Adaptor Proteins, Phospho-Proteins
- Antigen References
-
- Fu C, et al. 1998. Immunity. 9:93-103.
- Kurosaki T & Tsukada S. 2000. Immunity. 12:1-5.
- Gauld SB, et al. 2002. Science. 296:1641-2.
- Minegishi Y, et al. 1999. Science. 286:1954-7.
- Gene ID
- 29760 View all products for this Gene ID
- UniProt
- View information about BLNK Phospho Tyr96 on UniProt.org
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