Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD70
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding between mouse CD27 (TNFRSF7) and mouse CD27L (CD70). The ND50 range: 0.3 – 1.5 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application
- RRID
- AB_2890724 (BioLegend Cat. No. 160801) AB_2890724 (BioLegend Cat. No. 160802)
Antigen Details
- Structure
- Homodimer
- Distribution
-
Activated T cells, B cells, NK cells, antigen presenting cells, activated plasmacytoid dendritic cells (pDCs), chronic B cell lymphocytic leukemia, and large B cell lymphomas.
- Function
- Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation. CD27L is induced by antigen receptor activation in B cells and downregulated by interaction with its receptor CD27.
- Interaction
- T cells, B cells, NK cells.
- Ligand/Receptor
- CD27
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Cancer Biomarkers, Cell Proliferation and Viability, Immunology
- Molecular Family
- Cytokines/Chemokines, Growth Factors, Immune Checkpoint Receptors, Soluble Receptors
- Antigen References
-
- Bowman MR, et al. 1994. J Immunol. 152:1756-61.
- Shaw J, et al. 2010. Blood. 115:3051-7.
- Keller AM, et al. 2009. Blood. 113:5167-75.
- Tesselaar K, et al. 1997. J Immunol. 159:4959-65.
- Akiba H, et al. 1999. J Immunol. 162:7058-66.
- Miller J, et al. 2010. J Neurosurg. 113:280-5.
- Kuka M, et al. 2013. J Immunol. 191:2282-9.
- Jang YS, et al. 2013. Clin Immunol. 149:379-87.
- Gene ID
- 21948 View all products for this Gene ID
- UniProt
- View information about CD70 on UniProt.org
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