Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2922609 (BioLegend Cat. No. 379702)
Antigen Details
- Structure
- Human ATG3 is a 314 amino acid protein with a molecular mass of 36 kD
- Distribution
-
Expressed in testis and bone marrow stromal cell
- Function
- E2-conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2, or MAP1LC3A).
- Interaction
- Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.
- Ligand/Receptor
- ATG8
- Biology Area
- Cell Biology, Cell Death, Immunology
- Molecular Family
- Apolipoproteins, Autophagosome Markers
- Antigen References
-
- Isei T, et al. 2002. J Biol Chem. 277:13739.
- Silke M. et al. 2009. Hum Genet. 128:453.
- Ozlem O, et al. 2012. Apoptosis. 17:810.
- Gene ID
- 64422 View all products for this Gene ID
- UniProt
- View information about ATG3 on UniProt.org
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