Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide from human SHP-2
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1.0??g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody recognizes endogenous human and mouse SHP-2 proteins in K-562, HeLa, HEK293, and NIH/3T3 cell lysates by WB.
- RRID
- AB_2894536 (BioLegend Cat. No. 948201) AB_2894536 (BioLegend Cat. No. 948202)
Antigen Details
- Structure
- SHP-2 is a 593 amino acid protein with a molecular mass of 68 kD.
- Distribution
-
Cytoplasm and Nucleus
- Function
- SHP-2 regulates cell proliferation, apoptosis, invasion, and metastasis.
- Interaction
- SHP-2 interacts with PD1, EGFR, HGF receptor, RET, FGFR2, FGFR3, PI3K/AKT, and TLR3 signaling pathways.
- Cell Type
- Lymphocytes, T cells, Th1
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immuno-Oncology, Immunology
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
-
- Hao C, et al. 2020. Oncogene. 39:7166-7180.
- Marie D., et al. 2008. Cell Signal. 20:453-9.
- Cheng Kui QU. 2000. Cell Research. 10:279-288.
- Gene ID
- 5781 View all products for this Gene ID
- UniProt
- View information about SHP-2 on UniProt.org
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