Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant human PD-L2 (B7-DC, CD273)-Fc chimera
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding of 0.2 ?g/mL biotinylated recombinant human PD-L2-Fc chimera (Cat. No. 785904) to 1 ?g/mL immobilized recombinant human PD-1 (CD279)-Fc chimera (Cat. No. 785106). ND50 range: 0.2 - 1 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.?
- RRID
- AB_2894535 (BioLegend Cat. No. 947803) AB_2894535 (BioLegend Cat. No. 947804)
Antigen Details
- Structure
- Dimer
- Distribution
-
Immature dendritic cells, mature dendritic cells, subset of macrophages, placental endothelium, and medullary thymic epithelial cells
- Function
- Inhibits T cell mediated proliferation and cytokine production by CD4+ T cells. Regulate T cell responses. PD-L2 expression is up-regulated on antigen-presenting cells by IFN-γ.
- Interaction
- Antigen-stimulated T and B cells, regulatory T cells, follicular T and B cells, dendritic cells, monocytes
- Ligand/Receptor
- PD-1 (CD279), RGMb
- Cell Type
- Antigen-presenting cells, Dendritic cells, Epithelial cells, Macrophages, Plasma cells
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Proliferation and Viability, Immunology
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors, Soluble Receptors
- Antigen References
-
- Latchman Y, et al. 2001. Nat. Immunol. 2:261.
- Brown JA, et al. 2003. J. Immunol. 170:1257.
- Youngnak P, et al. 2003. Biochem. Biophys. Res. Commun. 307:672.
- Singh AK, et al. 2011. Allergy. 66:155.
- Lewkowich IP, et al. 2013. Mucosal. Immunol. 6:728.
- Xiao Y, et al. 2014. J. Exp. Med. 211:943.
- Bardhan K, et al. 2016. Front Immunol. 7:550.
- Gene ID
- 80380 View all products for this Gene ID
- UniProt
- View information about CD273 on UniProt.org
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