Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human PLAUR (uPAR)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Block - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by blocking the binding of 3 ?g/mL biotinylated recombinant hPLAUR (uPAR) to 2 ?g/mL immobilized human u-Plasminogen Activator (Urokinase) (Cat. No. 755304). ND50 range: 4 - 20 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.?
- RRID
- AB_2894531 (BioLegend Cat. No. 946203) AB_2894531 (BioLegend Cat. No. 946204)
Antigen Details
- Structure
- Monomer
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes, and activated T cells
- Function
- Convert plasminogen to plasmin, cell adhesion, and chemotaxis
- Interaction
- Human PLAUR is able to bind uPA in a dose dependent manner.
- Ligand/Receptor
- uPA; LRP1 (CD91)
- Antigen References
-
1. Llinas P, et al. 2005. EMBO J. 24:1655.
2. Beaufort N, et al. 2004. J. Immunol. 172:540.
3. Tarui T, et al. 2001. J. Biol. Chem. 276:3983.
4. Qin DD, et al. 2014. Lupus 0961203314558857.
5. Thuno M, et al. 2009. Dis. Markers 27:157.
6. Alfano D, et al. 2009. Front Biosci. 14:3782.
7. Spinale JM, et al. 2014. Kidney Int. 10:1038.
8. Chounta A, et al. 2014. Liver Int. 2:601.
9. Harskamp RE and Roe MT. 2014. J. Am. Heart Assoc. 5:e001431. - Gene ID
- 5329 View all products for this Gene ID
- UniProt
- View information about PLAUR on UniProt.org
