Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CXCL5 (LIX)
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the chemotaxis induced by recombinant mouse CXCL5 (LIX) (Cat. No. 573302) at 0.8 ng/mL on mouse Baf3- mCXCR2 transfectant chemoattractant cells. ND50 range: 0.025 - 0.25 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2910492 (BioLegend Cat. No. 662053) AB_2910492 (BioLegend Cat. No. 662054)
Antigen Details
- Structure
- Chemokine
- Distribution
-
Endothelial cells, fibroblasts, monocytes, macrophages, platelets, alveolar type II cells
- Function
- CXCL5 chemoattracts and activates neutrophils during inflammation, and it is induced by LPS and inflammatory cytokines. NH2-terminal truncation enhances, whereas citrullination decreases the chemotactic properties of CXCL5.
- Interaction
- Neutrophils
- Ligand/Receptor
- CXCR2
- Antigen References
-
- Wuyts A, et al. 1999. J Immunol. 163:6155-63.
- Jeyaseelan S, et al. 2005. Am J Respir Cell Mol Biol. 32:531-9.
- Mei J, et al. 2010. Immunity. 33:106-17.
- Montier A, et al. 2010. J Biol Chem. 285:29750-9.
- Grommes J and Soehnlein O. 2011. Mol Med. 17:293-307.
- Gene ID
- 20304 View all products for this Gene ID
- UniProt
- View information about CXCL5 on UniProt.org
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