Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL-27.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565723 (BioLegend Cat. No. 676902)
Antigen Details
- Structure
- A heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40 related protein) and p28 (a newly discovered IL-12 p35-related protein).
- Distribution
-
Monocytes, macrophages, and dendritic cells (DCs).
- Function
- T cell proliferation and differentiation.
- Interaction
- Activated T cells, resting natural killer cells (NK), resting NKT cells, neutrophils, eosinophils, mast cells, hepatic stellate cells, hepatoma cells, and hepatocytes.
- Ligand/Receptor
- IL-27RA, also known as WSX-1 or TCCR, paired with gp130.
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Pflanz S, et al. 2002. Immunity 16:779.
2. Owaki T, et al. 2005. J. Immunol. 175:2191.
3. Batten M, et al. 2006. Nat. Immunol. 7:929.
4. Villarino AV, et al. 2006. J. Immunol. 176:237.
5. Stumhofer JS, et al. 2007. Nat. Immunol. 8:1363.
6. Awasthi A, et al. 2007. Nat. Immunol. 8:1380.
7. Pot C, et al. 2009. J. Immunol. 183:797.
8. Bender H, et al. 2009. Hepatology 50:585.
9. Bosmann M and Ward PA. 2013. J. Leukoc. Biol. 94:1159. - Gene ID
- 246778 View all products for this Gene ID
- UniProt
- View information about IL-27 on UniProt.org
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