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FITC anti-human IL-17A Antibody

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Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant full length human IL-17A
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Product Citations
  1. Feng R, et al. 2021. Scand J Immunol. 93:e13007. PubMed
  2. Zeng W, et al. 2017. Front Immunol. 0.806944444. PubMed
  3. D, et al. 2016. Tuberculosis. 95: 470-475. PubMed
  4. Touzot M, et al. 2015. Autoimmun Rev. 14:370. PubMed
  5. Brembilla N, et al. 2011. PLoS One. 15:18741. PubMed
  6. Du B, et al. 2020. Scand J Immunol. 91:e12872. PubMed
  7. Saraiva DP, et al. 2018. Front Immunol. 2.184027778. PubMed
  8. Hackstein CP, et al. 2022. Nat Commun. 13:7472. PubMed
  9. Chong WP, et al. 2020. Immunity. 53(2):384-397.e5.. PubMed
  10. Chen X, et al. 2009. Am J Respir Crit Care Med. 181:734. PubMed
  11. Trivedi S, et al. 2020. Elife. 9:00. PubMed
RRID
AB_961391 (BioLegend Cat. No. 512303) AB_961390 (BioLegend Cat. No. 512304)

Antigen Details

Structure
Cytokine; dimer; ~15 kD (Mammalian)
Bioactivity
Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells
Cell Sources
Activated T cell subpopulation
Cell Targets
Fibroblasts, epithelial and endothelial cells, stromal cells
Receptors
IL-17R
Cell Type
Tregs
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Hirota K, et al. 2007. J. Exp. Med. 204:41.
2. Furuzawa-Carballeda J, et al. 2007. Autoimmun. Rev. 6:169.
3. Witowski J, et al. 2007. Kidney Int. 71:514.
4. Gaffen SL, et al. 2006. Vitam. Horm. 74:255.
5. Hymowitz S, et al. 2001. EMBO J. 20:5332.

Gene ID
3605 View all products for this Gene ID
UniProt
View information about IL-17A on UniProt.org
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