Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This antibody was generated against Gross Cystic Disease Fluid Protein 15.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 1.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The BRST-2 clone D6 recognizes a 15 kD glycoprotein known as Gross Cystic Disease Fluid Protein-15 (GCDFP-15). Antigen retrieval is not required. The BRST-2 epitope is heat-sensitive; paraffin sections that have been heat fixed at 60°C may lose antibody binding sites.
- Application References
(PubMed link indicates BioLegend citation) -
- Yoshimura Y, et al. 2011. Jpn. J. Clin. Oncol. 41:358. (IHC) PubMed
- Fan CY, et al. 2000. Am. J. Surg. Pathol. 24(4):579. PubMed
- Wick MR, et al. 1989. Hum. Pathol. 20(3):281. PubMed
- Mazoujian G, et al. 1984. Am. J. Surg. Pathol. 8(1):43. PubMed
- Mazoujian G, et al. 1983. Am. J. Pathol. 110:105. PubMed
- Brown RW, et al. 1997. Am. J. Clin. Path. 107:12. PubMed
- RRID
- AB_2616964 (BioLegend Cat. No. 915106)
Antigen Details
- Structure
- BRST-2 (GCDFP-15) is a 17 kD protein.
- Distribution
-
Extracellular and nucleus.
- Function
- Diseases associated with BRST-2 include florid papillomatosis of the nipple and breast signet ring cell adenocarcinoma. Interacts with AZGP1.
- Biology Area
- Cancer Biomarkers, Cell Biology
- Gene ID
- 5304 View all products for this Gene ID
- UniProt
- View information about BRST-2 on UniProt.org
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