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PE anti-mouse CD193 (CCR3) Antibody

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Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR3-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Bao H, et al. 2020. Mol Med Rep. 4.675. PubMed
  2. Wiesner D, et al. 2016. J Immunol. 196: 365 - 374. PubMed
  3. He W et al. 2018. Immunity. 49(6):1175-1190 . PubMed
  4. Gicheva N, et al. 2016. Biochem Biophys Res Commun. 479:1-4. PubMed
  5. Kline JM, et al. 2021. J Biol Chem. :100373. PubMed
  6. Verma M, et al. 2021. J Exp Med. 218:. PubMed
  7. Fend L, et al. 2014. Cancer Immunol Res. 2:1163. PubMed
  8. Ehrens A, et al. 2021. Cell Reports. 34(2):108621. PubMed
  9. Spath S, et al. 2022. iScience. 25:104998. PubMed
RRID
AB_2561533 (BioLegend Cat. No. 144505) AB_2561534 (BioLegend Cat. No. 144506)

Antigen Details

Structure
G-protein coupled, seven transmembrane domain receptor, 356 amino acids
Distribution

Eosinophils, basophils, mast, mononuclear phagocytes, platelets, hematopoietic progenitor, keratinocytes

Function
Co-receptor for HIV-1 and HIV-2, allergy
Ligand/Receptor
Eotaxin, eotaxin-2, eotaxin-3, RANTES, MCP-3, and MCP-4
Cell Type
Basophils, Eosinophils, Hematopoietic stem and progenitors, Mast cells, Platelets
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Zlotnik A, et al. 2006. Genome Biol. 7:243.
2. Kodali RB, et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24:1211.
3. Das AM, et al. 2006. J. Pharmacol. Exp. Ther. 318:411.
4. Huaux F, et al. 2005. Am. J. Pathol. 167:1485.
5. Puxeddu I, et al. 2006. J. Allergy Clin. Immunol. 117:103.

Gene ID
12771 View all products for this Gene ID
UniProt
View information about CD193 on UniProt.org
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