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Purified anti-human M-CSF Antibody

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Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human M-CSF
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2563444 (BioLegend Cat. No. 526002)

Antigen Details

Structure
Three isoforms with 256-554 amino acids, predicted molecular weight of approximately 30-70 kD.
Distribution

Cell membrane; single-pass membrane protein. Processed macrophage colony-stimulating factor 1: secreted, extracellular space.

Function
Controls the production, differentiation, and function of macrophages.
Interaction
Homodimer or heterodimer, disulfide-linked. Interacts with CSF1R.
Ligand/Receptor
M-CSFR or CSF1R (CD115).
Biology Area
Cell Biology, Cell Proliferation and Viability, Immunology
Molecular Family
Cytokines/Chemokines, Growth Factors
Antigen References

1. Kawasaki ES, et al. 1985. Science 230:291.
2. Wei S, et al. 2010. J. Leuko. Biol. 88:495.
3. Hodge JM, et al. 2011. PloS One 6:e21462.
4. Morandi A, et al. 2011. PloS One 6:e27450.
5. Erblich B, et al. 2011. PloS One 6:e26317.
6. MacDonald KP, et al. 2010. Blood 116:3955.

Gene ID
1435 View all products for this Gene ID
UniProt
View information about M-CSF on UniProt.org
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