Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human VEGF-165
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IP - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by?immunoprecipitation. This antibody can be used at 2 - 10 ?g/mL?for immunoprecipitation. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2564372 (BioLegend Cat. No. 662702)
Antigen Details
- Structure
- 232 amino acids with predicted molecular weight of approximately 27 kD.
- Distribution
-
Widely expressed.
- Function
- Endothelial cell proliferation, angiogenesis, and vasculogenesis.
- Interaction
- Binds to heparin sulfate, heparin, and neuropilin-1. Interacts with vascular endothelial cells, monocytes, and macrophages, which express VEGFR1; this induces proliferation of endothelial cells and stimulates the migration of monocytes and macrophages.
- Ligand/Receptor
- FLT1/VEGFR1 and KDR/VEGFR2.
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Signal Transduction
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Conn G, et al. 1990. Proc. Natl. Acad. Sci. USA 87:1323.
2. Gerber H, et al. 2002. Nature 417:954.
3. Shibuya M, et al. 2006. J. Biochem. Mol. Biol. 39:469.
4. Reddy K, et al. 2008. Angiogenesis 11:257.
5. Monaghan-Benson E, et al. 2010. Am. J. Pathol. 177:2091.
6. Koch S and Claesson-Welsh L. 2012. Cold Spring Harb. Perspect. Med. 2:a006502.
7. Cao Y. 2014. Nat. Rev. Endocrinol. 10:530.
8. Lui KO. 2014. Curr. Stem Cell Res. Ther. 9:396. - Gene ID
- 7422 View all products for this Gene ID
- UniProt
- View information about VEGF-A on UniProt.org
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