Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ELISA Capture - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 1.0 - 4.0 ?g/mL is recommended. To obtain a linear standard curve, serial dilutions of PCSK9 recombinant protein ranging from 58.6 to 3750 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The purified M1118E3 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated Poly5250 antibody (Cat. No. 525004) as the detection antibody and Recombinant Human PCSK9 (ELISA Std.) (Cat. No. 592509)
- RRID
- AB_2783350 (BioLegend Cat. No. 537502)
Antigen Details
- Structure
- Monomer
- Distribution
-
Hepatocytes, neuro-epithelioma, colon carcinoma, Schwann cells
- Function
- PCSK9 regulates LDLR, VLDLR, APOER, and APOER2 levels, and, therefore LDLc level. PCSK9 is regulated by SREBP-2
- Interaction
- Hepatocytes
- Ligand/Receptor
- LDLR, VLDLR, APOB, LRP1, LRP8
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Signal Transduction
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
- Seidah NG, et al. 2003. Proc Natl Acad Sci USA. 100:928.
- Naureckiene S, et al. 2003. Arch Biochem Biophys. 420:55.
- Costet P, et al. 2008. Trends Biochem Sci. 33:426.
- Tibolla G, et al. 2011. Nutr Metab Cardiovasc. Dis. 21:835.
- Gene ID
- 255738 View all products for this Gene ID
- UniProt
- View information about PCSK9 on UniProt.org
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