Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human EGF, amino acids Asn971 - Arg1023, with an N-terminal Met (Accession# P01133) was expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IP - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunoprecipitation. For immunoprecipitation, the suggested use of this reagent is 2-10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2566190 (BioLegend Cat. No. 679502)
Antigen Details
- Structure
- 54 amino acids wtih a predicted molecular weight of approximately 6 kD.
- Distribution
-
Mammary gland cells, macrophages, gut epithelial cells, cells in the nervous system, and the kidney.
- Function
- EGF is a potent mitogen for many cells in culture, and in vivo, it induces the proliferation and the differentiation of the skin, cornea, lungs, trachea, and among other tissues. Processing of pro EGF in different tissues is not equally efficient. The precursor is processed to mature EGF in the submaxillary glands, pancreas, small intestine, and the mammary glands. EGF is fully processed, stored in secretory granules, and secreted in saliva. In the kidney, EGF is present in unprocessed or intermediated forms on the cell surface.
- Interaction
- EGFR, RHBDF2, RHBDF1, and ERAD.
- Ligand/Receptor
- EGFR.
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Immunology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
1. Henson ES and Gibson SB. 2006. Cell Signal. 18:2089.
2. Burgess AW, et al. 2003. Mol. Cell. 12:541.
3. Imai Y, et al. 1982. Cancer Res. 42:4394.
4. Barnes DW. 1982. J. Cell. Biol. 93:1.
5. Heo JS, et al. 2006. Am. J. Physiol. Cell Physiol. 290:C123.
6. Bodnar RJ. 2013. Adv. Wound Care (New Rochelle). 2:24.
7. Zeng F, et al. 2014. Semin. Cell Dev. Biol. 28:2. - Gene ID
- 1950 View all products for this Gene ID
- UniProt
- View information about EGF on UniProt.org
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