Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ELISA Capture - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of? 2.0 - 8.0 ?g/mL is recommended. To obtain a linear standard curve, serial dilutions of IFN-α2 recombinant protein ranging from 12.5 to 800 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The pure M4509E12 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated BL25372 antibody (Cat. No. 537204) as the capture antibody and Recombinant Human IFN-a2 (ELISA Std.) (Cat. No. 592709)
- RRID
- AB_2783346 (BioLegend Cat. No. 537102)
Antigen Details
- Distribution
-
IFN-α is ubiquitously expressed.
- Function
- IFN-α stimulates cytotoxic T lymphocytes and natural killer cell function. IFN-α has immunomodulatory and antiviral properties. IFNα2a induces CXCL10 in human microvascular endothelial cells and pulmonary artery smooth muscle cells. It is induced by viral infection.
- Interaction
- A variety of cells express the IFNα receptor (IFNAR).
- Ligand/Receptor
- IFNAR complex has two components, IFNAR1 and IFNAR2.
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Soluble Receptors
- Antigen References
-
- Bose A and Baral R. 2007. Immunol Lett. 108:68.
- Zhao W, et al. 2008. J Immunol. 180:5483.
- Badiger R, et al. 2012. Plos One. 7:e46779.
- Aghemo A, et al. 2010. Nat Rev Gastroenterol Hepatol. 7:485.
- Becker-Merok A, et al. 2013. Lupus. 22:155.
- Mukherjee KK, et al. 2012. Indian J Med Res. 136:54.
- Gene ID
- 3440 View all products for this Gene ID
- UniProt
- View information about IFN-alpha2 on UniProt.org
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