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重組人色素上皮源性因子蛋白

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產品編號bs-41083P
英文名稱Recombinant human PEDF protein, His
中文名稱重組人色素上皮源性因子蛋白
別    名pigment epithelium-derived factor; Serpin-F1; Stromal cell-derived factor 3; SDF-3; Caspin; Alpha 2 antiplasmin; EPC 1; EPC1; PIG 35; PIG35; Pigment epithelium derived factor; Proliferation inducing protein 35; SERPIN F1; Serpin peptidase inhibitor clade F member 1; SERPINF 1; SERPINF1; PEDF_HUMAN; Recombinant human PEDF protein, His  
理論分子量45.2kDa
檢測分子量55 kDa
性    狀Lyophilized or Liquid
濃    度>0.5 mg/ml
物    種Human
序    列20-418/418
純    度>95% as determined by SDS-PAGE
純化方法AC
內毒素Not analyzed
表達系統(tǒng)E.coli
活性Not tested
標簽His
緩 沖 液20 mM Tris-HCl (pH=8.0) with 8 M Urea
保存條件Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.

SWISS:
P97298

Gene ID:
5176

產品圖片
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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