| 產(chǎn)品編號 | bs-41361P |
| 英文名稱 | Recombinant human TMPRSS2 protein |
| 中文名稱 | 重組人絲氨酸蛋白酶10 |
| 別 名 | Epitheliasin; PRSS10; Serine protease 10; TMPRSS2; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain; Transmembrane protease, serine 2; Transmembrane protease, serine 2, EC 3.4.219; Transmembrane protease, serine 2, EC 3.4.219; D16Ertd61e. |
| 理論分子量 | 44.8kDa |
| 檢測分子量 | 40 kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5 mg/ml |
| 序 列 | 108-492/492 |
| 純 度 | >90% by SDSD-PAGE |
| 內(nèi)毒素 | Not analyzed |
| 活性 | No tested |
| 標(biāo)簽 | N-His Tag |
| 緩 沖 液 | PBS pH7.5 |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors (1,2). The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland (3,4). TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain (3). TMPRSS2 is expressed as a full length form and a cleaved protease domain (5) and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis (6). SWISS: O15393 Gene ID: 7113 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 86% as determined by reducing SDS-PAGE. |
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