| 產(chǎn)品編號 | Y-0198P |
| 英文名稱 | Nogo-66 1-40 (NEP 1-40) Peptide |
| 中文名稱 | Nogo-66 (1-40)多肽 |
| 別 名 | Nogo-66(1-40) antagonist peptide; NEP 1-40 peptide; Reticulon-4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5. |
| 理論分子量 | 4.622kDa |
| 性 狀 | Lyophilized powder |
| 物 種 | human |
| 序 列 | Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide, MW: 4622.35 |
| 純化方法 | HPLC |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 | Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent. Sequence: Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35 活性多肽：Nogo-66 NEP1-40，能促進(jìn)神經(jīng)細(xì)胞軸突再生；Nogo-66的末端片斷能促進(jìn)脊髓損傷動物模型神經(jīng)軸突的再生，并改善功能恢復(fù)。 Nogo-A的再生活性片段Nogo-66具有明顯的誘導(dǎo)神經(jīng)干細(xì)胞向膠質(zhì)細(xì)胞分化的作用，Nogo-66的膠質(zhì)分化誘導(dǎo)作用是通過NgR介導(dǎo)的。 氨基酸序列：Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35） |
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