| 產(chǎn)品編號 | bs-2049P |
| 英文名稱 | Recombinant human EGF protein, GST |
| 中文名稱 | 重組人表皮生長因子 |
| 別 名 | rhEGF; rh-Epidermal growth factor; Recombinant full length EGF protein. Beta urogastrone; Epidermal Growth Factor; URG; Urogastrone; EGF; EGF_HUMAN; Epidermal Growth Factor; HOMG4; OTTHUMP00000219721; OTTHUMP00000219722; Recombinant human EGF protein, GST |
| 理論分子量 | 32.2kDa |
| 檢測分子量 | 32 kDa |
| 性 狀 | Lyophilized powder |
| 濃 度 | ＞0.5 mg/ml |
| 物 種 | Human |
| 序 列 | 971-1023/1207 |
| 純 度 | >95% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達系統(tǒng) | E.coli |
| 活性 | Not tested |
| 標簽 | GST |
| 緩 沖 液 | Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Function : Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action. EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. This product is an active protein and may elicit a biological response in vivo, handle with caution. SWISS: P01133 Gene ID: 1950 重組人表皮生長因子rhEGF，是人生長因子中的一種，是由53個氨基酸組成的相對分子量為6.2KDa的小分子多肽。重組人表皮生長因子作為一種強有力的細胞分裂因子，具有多種生物活性。 主要表現(xiàn)為： 1、在體內(nèi)刺激皮膚組織、角膜和氣管上皮組織的生長繁殖； 2、加速角膜、皮膚等表皮創(chuàng)傷的修復(fù)； 3、抑制胃酸分泌； 4、促進人皮膚上皮細胞、角膜上皮細胞、哺乳動物上皮細胞生長； 5、增強表皮細胞的蛋白質(zhì)、DNA、RNA的合成和細胞代謝等。 重組人表皮生長因子不僅具有促進皮膚和黏膜創(chuàng)傷的愈合，防治潰瘍以及消炎鎮(zhèn)痛的作用，而且能有效促進和調(diào)節(jié)表皮細胞的生長和增殖，表皮細胞生長因子對保護和療養(yǎng)皮膚、黏膜具有十分獨特的功效。廣泛應(yīng)用于治療燒傷、燙傷、手術(shù)傷、機械傷、皮膚潰瘍、激光美容等。 重組人表皮生長因子在護膚保健化妝品中也具有廣泛的應(yīng)用價值和市場前景。重組人表皮生長因子在護膚保健化妝品中的作用如下： ①嫩膚護膚作用。重組人表皮生長因子能促進皮膚細胞對營養(yǎng)物質(zhì)的吸收，加速細胞的新陳代謝，促進皮膚細胞的分裂和增長，促進透明質(zhì)酸和糖蛋白的合成。 ②促進細胞再生和組織修復(fù)。重組人表皮生長因子有促進皮膚和黏膜創(chuàng)傷面的愈合作用，并減少疤痕攣縮和皮膚畸形增生。用于治療疤痕，尤其是痤瘡后遺的疤痕疙瘩療效較好。 ③防曬作用。重組人表皮生長因子能促進新生細胞的生長，替代受紫外線照傷的細胞，以降低皮膚中黑色素細胞的數(shù)量。 重組人表皮生長因子在化妝品中應(yīng)用具有很好的安全性、經(jīng)濟性。臨床實驗發(fā)現(xiàn)重組人表皮生長因子雖然能很快誘導(dǎo)皮膚細胞中多角形細胞增殖，但經(jīng)過一段時間后便達到生理平衡，細胞不再無限增殖，即表皮生長因子具有使皮膚細胞更新又不導(dǎo)致細胞畸型的特性。 重組人表皮生長因子價格雖然較昂貴，但它的作用劑量小只要有10-9克數(shù)量級的表皮生長因子存在就可發(fā)揮相應(yīng)的功能，所以該類產(chǎn)品性能價格比極佳。 |
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