| 產(chǎn)品編號(hào) | bs-2149P |
| 英文名稱 | SPRN Antibody Blocking Peptide |
| 中文名稱 | 新朊蛋白封閉多肽 |
| 別 名 | rCG47959; shadow of prion protein; SHO; Protein shadoo; bA108K14.1; C630041J07; FLJ41197; SPRN; Shadow of prion protein precursor; SPRN_MOUSE; SHADOO. |
| 性 狀 | Lyophilized powder |
| 物 種 | mouse |
| 純化方法 | 1 |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 | bs-2149P is one synthetic peptide derived from mouse Shadow. Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Constitutively expressed in normal adult brain, cellular PrP (PrP(C)) is sensitive to proteinase K digestion and is converted to the disease form, PrPSc, through alterations in protein folding conformation, which make it resistant proteases. SPRN (shadow of prion protein), also known as SHO or SHADOO, is a 151 amino acid cytoplasmic protein that is mainly expressed in brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and may act as a modulator for the biological actions of normal and abnormal PrP. In humans, mutations in the gene encoding SPRN may be associated with variant and sporadic Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably fatal SWISS: Q8BWU1 Gene ID: 212518 |
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