| 產(chǎn)品編號(hào) | bs-2558P |
| 英文名稱 | EGFRvIII Antibody Blocking Peptide |
| 中文名稱 | 表皮生長(zhǎng)因子受體III型突變體封閉多肽 |
| 別 名 | GFRvIII; Epidermal growth factor receptor variant type Ⅲ; epidermal growth factor receptor isoform a variant. |
| 性 狀 | Lyophilized powder |
| 物 種 | human |
| 純化方法 | HPLC |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. Despite this, EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown to be important in driving tumor progression and often correlates with poor prognosis. It is clear that EGFRvIII is expressed in a considerable proportion of patients with glioblastoma multiforme (GBM). SWISS: P00533 Gene ID: 1956 表皮生長(zhǎng)因子受體3型突變體抗原 |
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