| 產(chǎn)品編號(hào) | bs-1704P |
| 英文名稱 | SERPINE1 Antibody Blocking Peptide |
| 中文名稱 | 纖溶酶原激活物抑制因子封閉多肽 |
| 別 名 | Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) proteinase inhibitor; Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin E1; Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; Serpin peptidase inhibitor clade E; Serpine 1; Serpine1. |
| 性 狀 | Lyophilized powder |
| 物 種 | human |
| 純化方法 | HPLC |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder. SWISS: P05121 Gene ID: 5054 PAI-1是一種單鏈糖蛋白，其生理作用很多： （1）與組織型纖溶酶原激活物（tissue plasminogen activator，t-PA）形成1：1的復(fù)合物而使t-PA失活; （2）保護(hù)基底膜不被血漿來(lái)源的酶所降解; （3）保護(hù)細(xì)胞間的接觸面而維持組織結(jié)構(gòu)的完整性; （4）在結(jié)締組織演變、凝血、纖溶、補(bǔ)體激活和炎癥反應(yīng)等過(guò)程中具有抑制蛋白降解作用; （5）在細(xì)胞周期中，PAI-1轉(zhuǎn)錄水平的變化及其在細(xì)胞內(nèi)的積聚，對(duì)細(xì)胞形態(tài)的維持、細(xì)胞與其間質(zhì)的粘附、細(xì)胞增殖、信號(hào)轉(zhuǎn)導(dǎo)及基因表達(dá)等都有重要意義; |
我要詢價(jià)
*聯(lián)系方式：
(可以是QQ、MSN、電子郵箱、電話等，您的聯(lián)系方式不會(huì)被公開(kāi))
*內(nèi)容：
