產(chǎn)品編號(hào) | bs-4609P |
英文名稱(chēng) | CD105 Antibody Blocking Peptide |
中文名稱(chēng) | 內(nèi)皮糖蛋白封閉多肽 |
別 名 | END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen; EGLN_HUMAN; AI528660; AI662476; S-endoglin; SN6. NULL |
性 狀 | Lyophilized powder |
物 種 | human |
純化方法 | HPLC |
活性 | Not tested |
保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
產(chǎn)品介紹 | CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. SWISS: P17813 Gene ID: 2022 CD105(Endoglin):CD105是一種存在于細(xì)胞表面的同源二聚體跨膜糖蛋白,是TGF-β受體復(fù)合物的組成部分,是TGF-β的附屬受體,能與多種TGF-β超家族成員結(jié)合尤其與TGF-β1、TGF-β3有很高的親和力,調(diào)節(jié)TGF-βs與其受體結(jié)合而參與信號(hào)傳導(dǎo),是內(nèi)皮細(xì)胞增殖相關(guān)膜抗原,在培養(yǎng)的高增殖活性?xún)?nèi)皮細(xì)胞和許多惡性腫瘤組織血管內(nèi)皮細(xì)胞中高表達(dá),參與血管生成,但其在血管生成調(diào)節(jié)中的作用機(jī)制尚未闡明。主要用于各種惡性腫瘤組織中的血管生成的研究. |
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