| 產(chǎn)品編號 | bs-11422P |
| 英文名稱 | NPS Antibody Blocking Peptide |
| 中文名稱 | 神經(jīng)肽S封閉多肽 |
| 別 名 | NeuropeptideS; Neuropeptide-S; Neuropeptide S; NPS; NPS_HUMAN. NULL |
| 性 狀 | Lyophilized powder |
| 物 種 | human |
| 序 列 | NPS(70-89aa) |
| 純化方法 | HPLC |
| 活性 | Not tested |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Neuropeptides are regulators of synaptic transmission and their effects are mediated by G-protein coupled receptors. NPS (Neuropeptide S) is a 20 amino acid peptide cleaved from a larger precursor that contains a hydrophobic signal peptide and proteolytic cleavage processing sites. The N-terminal residue of NPS is always a serine regardless of the species. NPS is predominantly found in the central nervous system and plays an important role regulating sleep/wake functions, locomotion, arousal/anxiety responses and food intake. NPS functions by binding and activating its receptor, NPSR, and increasing intracellular calcium levels thereby acting as an excitatory transmitter. In addition, NPS stimulates the hypothalamo-pituitary adrenal (HPA) axis via the release of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP). NPS and its receptor NPSR may also play a role in asthma pathogenesis. SWISS: P0C0P6 Gene ID: 594857 神經(jīng)肽S(Neuropeptide S)是2002年發(fā)現(xiàn)的生物活性肽,具有促覺醒、抗焦慮和增強記憶力的作用。NPS前體1nRNA主要表達(dá)在一系列腦區(qū),包括藍(lán)斑核、Barrington核以及臂旁外側(cè)核和腦干中的三叉神經(jīng)感覺主核等,還包括杏仁核、背內(nèi)側(cè)核以及下丘腦中。而NPS受體(NPSR)則在腦區(qū)中具有廣泛和高水平的表達(dá)。NPSR在基底神經(jīng)節(jié)中有大量表達(dá),NPSR這一部分在自主運動調(diào)節(jié)中起著十分重要的作用。 |
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