| 產(chǎn)品編號 | bs-10160P |
| 英文名稱 | Hepcidin-25 Peptide |
| 中文名稱 | 鐵調(diào)節(jié)蛋白25多肽 |
| 別 名 | Hamp; HEPC; HEPC_HUMAN; Hepc20; Hepc25; HEPCIDIN; Hepcidin 20; Hepcidin 25; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1; LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor. 鐵調(diào)素; 海帕西啶; 肝臟抗菌多肽; 抗菌肽; 鐵調(diào)節(jié)蛋白; |
| 理論分子量 | 2.78940kDa |
| 性 狀 | Lyophilized powder |
| 物 種 | human |
| 序 列 | Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bonds 7-23, 10-13, 11-19, 14-22) |
| 純化方法 | HPLC |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. Sequence: Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bonds 7-23, 10-13, 11-19, 14-22) C113H170N34O31S9 MW: 2789.40 CAS: [342790-21-0] Hepcidin是一種由肝臟細(xì)胞產(chǎn)生的具有廣譜殺菌抑菌作用的抗菌肽，屬于防御性蛋白家族。Hepcidin在肝臟合成時，首先產(chǎn)生一種早期多肽，由84個氨基酸殘基組成。在其Gly24和Ser25之間存在一個酶切位點，當(dāng)酶切去除其24個氨基酸殘基的信號肽后，形成由60個氨基酸殘基組成的前體肽(pro-Hepcidin)，并通過轉(zhuǎn)運進(jìn)入血液循環(huán)，最后由前肽轉(zhuǎn)化酶(propeptide convertase)在N端的不同位點剪接生成3種不同的成熟小肽，分別由20、22、25個氨基酸組成，其中以25個氨基酸為其主要形式和主要活性部分，稱作Hepcidin-25。含有25個氨基酸的小分子多肽蛋白主要在肝臟表達(dá)，其中有8個半胱氨酸---含25個氨基酸的小分子多肽蛋白是活性片段,和許多富含半胱氨酸的抗菌肽類似具有顯著的抗菌作用。經(jīng)研究表明Hepcidin25是機體鐵穩(wěn)態(tài)調(diào)控途徑中關(guān)鍵性效應(yīng)分子,其主要生物學(xué)功能在于調(diào)節(jié)小腸細(xì)胞對鐵的吸收，也有學(xué)者稱為：抗菌肽Hepcidin25。由于該蛋白多肽中有多個半胱氨酸構(gòu)成，故導(dǎo)致二硫鍵的形成---形成多聚體蛋白。 |
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