| 產(chǎn)品編號(hào) | Y-0430 |
| 英文名稱 | LL-37 active peptide |
| 中文名稱 | 抗菌肽CAMP/LL-37抗菌活性多肽 |
| 別 名 | Antibacterial protein LL-37; LL-37 peptide; 18 kDa cationic antimicrobial protein; Antibacterial protein FALL-39; CAMP; CAMP_HUMAN; CAP 18; CAP-18; CAP18; cathelicidin antimicrobial peptide; Cathelicidin antimicrobial peptide precursor; Cathelin-like protein; Cathelin-related antimicrobial peptide; CATHL3; Cationic antimicrobial protein CAP 18; Cationic antimicrobial protein, 18-KD; CLP; Cnlp; Cramp; CRAMP, mouse, homolog of; FALL 39; FALL 39 peptide antibiotic; FALL-39 peptide antibiotic; FALL39; hCAP 18; hCAP-18; hCAP18; HSD26; LL 37; LL37; MCLP; mcramp. LL-37抗菌肽; LL-37抗菌多肽; LL-37多肽; |
 | Specific References (1) | Y-0430 has been referenced in 1 publications. [IF=6.96] Wanqing Xie. et al. Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke. J CEREBR BLOOD F MET. ;(): |
| 性 狀 | Lyophilized powder |
| 序 列 | FKRIVQRIKDFLRNLVPRTES |
| 純化方法 | HPLC |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. FALL-39 precursor (FALL-39 peptide antibiotic, cationic anti-microbial protein, CAMP, CAP-18, HSD26) is a cathelicidin anti-microbial protein that contains the antibacterial peptide LL-37 (amino acids 134-170). In contrast to the defensins, which are cysteine-rich peptides that fold in ∫-pleated sheets, LL-37 is a cysteine-free peptide that can adopt an amphipathic ?-helical conformation. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils. The mouse and rat ortholog, CRAMP (cathelin-related antimicrobial peptide), is also part of the cathelicidin family of host defense peptides. These include precursors of potent antimicrobial peptides that direct antimicrobial activity against various microbial pathogens and also activate mesenchymal cells during wound repair. CRAMP is expressed in testis, spleen, stomach and intestine. |
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