| 產(chǎn)品編號(hào) | bs-37001P |
| 英文名稱 | Alarelin, Acetate |
| 中文名稱 | 醋酸阿拉瑞林 |
| 別 名 | ALARELIN ACETATE; DES-GLY10,[D-ALA6]-LH-RH ETHYLAMIDE ACETATE SALT; 79561-22-1; 148029-26-9; MFCD18782231; (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH acetate 阿拉瑞林;丙氨瑞林;醋酸阿拉瑞林;腺苷-5-一磷酸; |
| 性 狀 | Lyophilized powder |
| 序 列 | Pyr-HWSY(d-A)LRP-NHEt |
| 純化方法 | HPLC |
| 活性 | Yes |
| 保存條件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Alarelin (Gonadotrophin-releasing hormone) is a synthetic LH-RH agonist that is found in higher amounts than that of LH-RH in rat hypophyseal stimulation of gonadotropin secretion in vivo and in vitro and in ovulation inductions. Alarelin is known for its induction of ovulation. Alarelin acetate is the acetate form of a hypothalamic peptide that stimulates the release of FSH and LH from the pituitary gland. Alarelin acetate peptide is a single, non-glycosylated polypeptide chain containing 9 amino acids, having a molecular mass of 1167.3 Dalton and a Molecular formula of C56H78N16O12 x C2H4O2. The CAS No. is 79561-22-1. 阿拉瑞林（gonadotrophin releasing hormoneanalogue(GnRH-A)，又名丙氨瑞林，為人工合成的促性腺激素釋放激素(GnRH)的九肽類似物,其藥效是母體的15倍。用藥初期可刺激垂體釋放促黃體生成素(LH)和促卵泡素(FSH),引起卵巢源性甾體激素短暫升高;重復(fù)用藥可抑制垂體釋放LH和FSH,使血中的雌二醇水平下降,達(dá)到藥物去卵巢的作用，同時(shí)對(duì)子宮內(nèi)膜癌的相關(guān)癌基因 ras、neu、myc 的表達(dá)具有調(diào)控作用。臨床上主要用于促排卵、治療卵巢功能異常引起的不育癥、子宮內(nèi)膜異位癥及子宮肌瘤等和提高妊娠率。 |
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