| 產(chǎn)品編號 | bs-49050P |
| 英文名稱 | Recombinant CDV Fusion Glycoprotein F0 protein, His |
| 中文名稱 | 重組犬瘟熱病毒融合糖蛋白F0蛋白 |
| 別 名 | Canine Distemper Virus Fusion Glycoprotein F0; Fusion glycoprotein F0 · Canine distemper virus (strain Onderstepoort) (CDV); FUS_CDVO; Recombinant CDV Fusion Glycoprotein F0 protein, His |
| 理論分子量 | 52kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | ＞0.5 mg/ml |
| 物 種 | CDV |
| 序 列 | 136-600/661 |
| 純 度 | >95% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內毒素 | Not analyzed |
| 表達系統(tǒng) | E.coli |
| 活性 | Not tested |
| 標簽 | His |
| 緩 沖 液 | 10 mM Tris-HCl (pH=8.0) with 8 M Urea and 10% Glycerol. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis SWISS: N/A Gene ID: N/A |
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