| 產(chǎn)品編號 | bs-43588P |
| 英文名稱 | Recombinant human EPOR protein, C-His (HEK293) |
| 中文名稱 | 重組人紅細(xì)胞生成素受體蛋白 |
| 別 名 | erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor; EPOR_HUMAN; MGC138358. |
| 理論分子量 | 25.9kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >0.5mg/ml |
| 物 種 | Human |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not tested |
| 表達(dá)系統(tǒng) | HEK293 cell |
| 標(biāo)簽 | C-His |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis. SWISS: P19235 Gene ID: 2057 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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