| 產(chǎn)品編號(hào) | bs-42293P |
| 英文名稱 | Recombinant human NKX2-1 protein, N-Trx-His |
| 中文名稱 | 重組人甲狀腺核轉(zhuǎn)錄因子-1蛋白 |
| 別 名 | NKX21_HUMAN; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1 (TTF-1); Thyroid-specific enhancer-binding protein (T/EBP); NKX2A; TITF1; TTF1; TTF-1; NK2 homeobox 1; BCH; BHC; NK-2; TEBP; NMTC1; T/EBP; |
| 理論分子量 | 25.3kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | >1mg/ml |
| 物 種 | Human |
| 序 列 | 40-111/371 |
| 純 度 | >90% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | N-Trx-His |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 150mM Nacl |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011] SWISS: P43699 Gene ID: 7080 結(jié)合并激活甲狀腺特異性基因（如甲狀腺球蛋白，甲狀腺過(guò)氧化物酶和促甲狀腺激素受體）啟動(dòng)子的轉(zhuǎn)錄因子；對(duì)于維持甲狀腺分化表型至關(guān)重要；可能在肺部發(fā)育和表面活性劑穩(wěn)態(tài)中起作用；與GRHL2形成一個(gè)調(diào)節(jié)環(huán)，該環(huán)調(diào)節(jié)肺上皮細(xì)胞形態(tài)的發(fā)生和分化；抑制生物鐘轉(zhuǎn)錄阻遏物NR1D1的轉(zhuǎn)錄等。 |
| 產(chǎn)品圖片 |  The purity of the protein is greater than 90% as determined by reducing SDS-PAGE. |
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