| 產(chǎn)品編號 | bs-41578P |
| 英文名稱 | Recombinant Human p-Tau181 Protein |
| 中文名稱 | 重組人磷酸化微管相關(guān)蛋白 |
| 別 名 | MAPTL; MTBT1; TAU |
| 理論分子量 | 48kDa |
| 性 狀 | Lyophilized or Liquid |
| 物 種 | Human |
| 序 列 | 1-441/441 |
| 表達(dá)系統(tǒng) | E.coli |
| 標(biāo)簽 | C-His |
| 緩 沖 液 | 0.15 M Phosphate buffered saline (pH=7.4) |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 | Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. SWISS: P10636 Gene ID: 4137 tau蛋白是腦內(nèi)神經(jīng)元細(xì)胞支架蛋白之一.其正常功能是促進(jìn)微管蛋白組成微管,并維持已形成微管的穩(wěn)定性.參與維持細(xì)胞形態(tài)、信息傳遞、細(xì)胞分裂等重要生物學(xué)過程,是軸突生長發(fā)育和神經(jīng)元極性形成的不可缺少因素. 近年來發(fā)現(xiàn)tau蛋白與一些中樞神經(jīng)系統(tǒng)變性疾病密切相關(guān),尤其是神經(jīng)Tau具有啟動(dòng)微管系統(tǒng)的裝配以及穩(wěn)定微管系統(tǒng)的作用，該蛋白的錯(cuò)誤折疊與老年性癡呆等神經(jīng)退行性疾病密切相關(guān). |
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