英文名稱：NGB
中文名稱：腦紅蛋白/神經(jīng)血紅蛋白/神經(jīng)球蛋白抗體
別 名：neuroglobin; NGB; NGB_MOUSE.
研究領(lǐng)域：細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡
抗體來源：Rabbit
克隆類型：Polyclonal
交叉反應(yīng)：Rat, (predicted: Human, Mouse, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用：ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：17kDa
細(xì)胞定位：細(xì)胞漿
性 狀：Liquid
濃 度：1mg/ml
免 疫 原：KLH conjugated synthetic peptide derived from mouse NGB:51-151/151
亞 型：IgG
純化方法：affinity purified by Protein A
儲 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹：This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Function:
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
Subunit:
Monomer. Homodimer and homotetramer; disulfide-linked.
Subcellular Location:
Perikaryon.
Tissue Specificity:
Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.
Post-translational modifications:
A redox disulfide bond regulates the heme pocket coordination and the rate of nitrite reduction to NO.
Phosphorylated in vitro by ERK1, ERK2 and PKA, and in vivo during hypoxia. Phosphorylation increases nitrite reductase activity.
Similarity:
Belongs to the globin family.
SWISS:
Q9ER97
Gene ID:
64242
Database links:
Entrez Gene: 58157 Human
Entrez Gene: 64242 Mouse
Entrez Gene: 85382 Rat
Omim: 605304 Human
SwissProt: Q9NPG2 Human
SwissProt: Q9ER97 Mouse
SwissProt: Q99JA8 Rat
Unigene: 274363 Human
Unigene: 64645 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Neuroglobin是一種在神經(jīng)組織和神經(jīng)沖動中攜氧、轉(zhuǎn)運(yùn)氧氣和供氧的特異性蛋白,并和神經(jīng)組織微循環(huán)有關(guān),神經(jīng)球蛋白能在缺氧的環(huán)境下保護(hù)神經(jīng)元.
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