Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
Direct ELISA - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 ?g per ml.?For Direct ELISA applications, a concentration range of 0.004 - 0.4 ?g/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Mahley RW. 2016. Arterioscler Thromb Vasc Biol. 36: 1305-1315.
- Riedel BC, et al. 2016. J Steroid Biochem Mol Biol. 160:134-47.
- Tai LM, et al. 2016. Acta Neuropathol. 131(5):709-23.
- Kim J, et al. 2014. Mol. Cells. 37:767
- Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312
- RRID
- AB_2728597 (BioLegend Cat. No. 852701) AB_2728598 (BioLegend Cat. No. 852702)
Antigen Details
- Structure
- Human APO E is a 299 amino acid protein with a molecular mass of 32 kD, and exists as 3 major isoforms, APO E2, APO E3, and APO E4.
- Distribution
-
Tissue sources: Ubiquitously expressed. Highest levels in liver, brain, spleen, adrenal gland, and kidney.
Cellular distribution: Plasma membrane, nucleus, endoplasmic reticulum, golgi apparatus, endosome, and extracellular.
- Function
- Apo E is involved in lipoprotein metabolism as well as the transport of fat-soluble vitamins, and cholesterol. Apo E also forms complexes with amyloid beta peptides leading to its uptake and degradation by microglia.
- Interaction
- Tau, amyloid beta
- Ligand/Receptor
- LDL receptor, SORL1
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Apolipoproteins
- Antigen References
-
- Mahley RW. 2016. Arterioscler Thromb Vasc Biol. 36: 1305-1315.
- Riedel BC, et al. 2016. J Steroid Biochem Mol Biol. 160:134-47.
- Tai LM, et al. 2016. Acta Neuropathol. 131(5):709-23.
- Kim J, et al. 2014. Mol. Cells. 37:767
- Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312
- Gene ID
- 348 View all products for this Gene ID
- UniProt
- View information about Apo E 109-116 on UniProt.org
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